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Tissue regeneration

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Creation of microbioenvironment for cells in order to study mechanisms of tissue formation for further tissue regeneration

Poral tissue-engineered constructions can be used to transport genetic material (a gene for the blood-vessel growth factor) and stimulate new tissue formation. In L. Shea’s laboratory, poral tissue-engineered nanoconstructions were created using polylactide-co-glycoside with encapsulated plasmids which carry gene insertions for transfection. It was found that porization increased the level of transgene expression in vivo. Transfected cells were at first found at the periphery of the construction, but in 4 months, transgene expression was observed throughout tissue construction. Stable expression of VEGE, born on the plasmid, led to increased density of blood vessels in transgene tissue compared to the control. Combining new nanoconstructions with gene delivery technology by the use of nonviral vectors will facilitate manipulations with different tissues in the future, favouring the development of the regenerative medicine.