The area of scientific interest includes a research on the role of poly-ADP-ribosylation in DNA reparation and aging, and on prion protein neurotoxicity. In 1992, A. Bürkle and K. Grube characterized positive correlation between poly-ADP-ribosylation activity (PARP1) in peripheral monocytes, induced by single-strand breaks, and life span of mammals. PARP1 activity in human peripheral monocytes was 5 times higher than in rat’s monocytes due to self-activation of the enzyme by means of ribosylation. The level of that enzyme was 2 times higher that content of ribosylated PARP-1 in the rat’s cells. As an organism grows older, PARP activity lowers both in human and in rats. On the other hand, PARP activity in immortalized lymphocytes taken from French long-lived persons, who were 100- and more years old, was higher than that in the cells belonging to the representatives of the control group (20- to 70 years old). Thus, high and carefully controlled PARP activity may promote life extension via supression of genome instability and oncogenesis.