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Anesthesiology

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МАРК kinases-dependent signaling pathways, which regulate chronic pain; the role of matrix metalloproteinases (MMPs) in the development of chronic pain
Numerous researches show that C-Jun N-terminal kinases (JNK) participate in tumor growth and in emergence of neuropathic pain. Prof. P. Gerner’s team studied JNK’s role in tumor growth and emergence of pain in the model of skin cancer. It was confirmed that JNK activation in the tumor mass, the spinal marrow and peripheral nerves contributed to the tumor growth. In this investigation, laboratory animals obtained injection of D-JNKI-1 (peptide, which is a selective inhibitor of JNK). As the result, tumor growth became slower, and reaction of laboratory animals at stimulation became less evident that demonstrated abatement in sensation of pain. Contrary, morphine injection (5 mg/kg), which is often used as analgesic at end-stage cancer, did not inhibit tumor growth. Research data show than inhibitors of JNK, such as D-JNKI-1, may be used to treat cancer and pain syndromes.