In prof. C. Schmitt’s laboratory, molecular mechanisms of cell’s response on stress are studies.
In prof. C. Schmitt’s laboratory, molecular mechanisms of cell’s response on stress are studies.
In the laboratory headed by K. Khrapko, particular interest is paid to the role of mtDNA somatic mutations in human aging. Scientists investigate the amount of mtDNA mutations in individual cells. Using such approach — evaluating the amount of mtDNA mutations in individual cells — it was found that the level of mtDNA deletions in human pigmented neurons was very high. Among other research guidelines of the laboratory, there are studies focused on mtDNA recombination and studies of mtDNA using microarrays. It is generally assumed that mtDNA mutations are created in the cells where those mutations are currently found. However, it was shown that cells with a particular mtDNA mutation tended to «cluster». Cells of those clusters are usually descendants of the single sell. Thus, mutations in mtDNA do not appear the cells of a cluster, but in progenitor cells, such as stem cells, or even earlier in the development. MtDNA mutatios in progenitor cells may be one of the major sources of mtDNA mutations in healthy aging tissue.
Many mitochondrial diseases are provoked by structural and functional changes in the complex I. Therefore, the major aim of the studies, T. Yagi’s team conducts, is to develop a therapy for compensation of the complex I defect. The most promising method is transfection with NADH gene of yeasts (Saccharomyces cerevisiae). That gene consist of one subunit (Ndi1) responsible for the NADH to
The main guideline of R. Freitas work is development of medical nanorobots for the diagnostics, the repair of damaged tissues, cells and organs (including those after cryopreservation), DNA analysis and correction, and elimination of bacteria and viruses. Using modern technologies, the manufacturing of nanorobots may start in the next 15–20 years. R. Freitas believes that the size of the device should not exceed 1×1×3 µm (without locomotor flagellums). Molecular manufacturing that uses nanotechnologies will enable to solve the problem of any organ treatment and restoration at the molecular level. Moreover, this technology will help to create artificial blood cells and cells with new functionality (for example, respirocytes that will help the human to breath underwater). In addition, it will help to stop the use of antibiotics in the treatment of any infectious diseases, cure cancer and heal any wounds, it will help to replace chromosomes and so, it will deliver people from genetic diseases. Nanorobots will enable to remove defects that have accumulated in the organism and cause aging. As the result, nanorobots may considerably prolong human youth and life span.
Dehydroepiandrosterone, also known as DHEA, is a hormone naturally produced in the brain and adrenal glands. DHEA has the ability to convert into other hormones such as testosterone and estrogen, depending on the body’s needs. Supplementing with DHEA may help boost energy levels, reduce the risk of cardiovascular disease & diabetes, improve memory and concentration, stimulate libido and improve physical performance.
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