Salk researchers identify how tumors cause immune cells to lose their ability to fight cancer, opening new avenues for therapies
Metastases can develop in the body even years after apparently successful cancer treatment. They originate from cancer cells that migrated from the original tumor to other organs, and which can lie there inactive for a considerable time. Researchers have now discovered how these “sleeping cells” are kept dormant and how they wake up and form fatal metastases. They have reported their findings in the journal Nature.
New atavistic model shows role of ancient genes in the spread of cancer
Scientists at VCU Massey Cancer Center have identified a protein that operates in tandem with a specific genetic mutation to spur lung cancer growth and could serve as a therapeutic target to treat the disease.
Treatment with the neoantigen cancer vaccine PGV-001 following standard-of-care adjuvant therapy was well tolerated and showed potential clinical benefit in patients with diverse tumor types with high risk of recurrence, according to results from a phase I clinical trial presented during Week 1 of the virtual AACR Annual Meeting 2021, held April 10-15.
WEHI researchers have discovered a key differentiation process that provides an essential immune function in helping to control cancer and infectious diseases.