Syros Pharmaceuticals Inc.

Precise control of genes is at the heart of cell identity and cellular function. When gene control is fundamentally altered or lost, healthy, normal cells transform into diseased cells — in essence, disease is caused by cell misidentity.

The nucleus, the source of gene control and the information processing center of the cell, has historically been a «black box» for drug development. A powerful convergence of new knowledge stemming from recent advances in genomics, biology and computational biology provides an unprecedented opportunity to understand the control of genes in disease state. Syros is based on this disruptive science of gene control. Syros founders’ seminal discovery of super-enhancers, a new class of gene control elements, enables us to understand the master switches used by a cell to maintain its identity. Importantly, our scientists found that in disease, these master switches also control the expression of genes driving disease. These gene control elements provide a road map for understanding and controlling disease causing genes.