The major research area of prof. A. Ryazanov is signaling molecules and protein synthesis, and their connection to cell growth, differentiation and aging. The scientist examines certified medicines only. If compounds having positive effect on life extension are found, the researcher won’t have to certify them again as they are already used in clinical practice. Finding of this study have not been published yet. In the future, this scientific project will probably be expanded. Clinical and histological analysis, as well as postmortem examination will be conducted in order to reveal how different compounds affect pathogenesis of cancer and age-related diseases. At the moment, A. Ryazanov leads the project on the large-scale screening of more than a thousand of medicines allowing to analyze their life extension effect in mice.
Place of employment — Department of Pharmacology, Robert Wood Johnson Medical School, USA.
Contacts — Piscataway. NJ 08854, USA(732) 235-5526ryazanag@umdnj. edu .
Publications — Autophagy regulates ageing in C. elegans. Hars ES, Qi H, Ryazanov AG, Jin S, Cai L, Hu C, Liu LF. Autophagy. 2007 Mar-Apr;3(2):93—5.A pharmacoproteomic approach implicates eukaryotic elongation factor 2 kinase in ER stress-induced cell death. Boyce M, Py BF, Ryazanov AG, Minden JS, Long K, Ma D, Yuan J. Cell Death Differ. 2008 Mar;15(3):589—99.Alpha-kinases: analysis of the family and comparison with conventional protein kinases. Drennan D, Ryazanov AG. Prog Biophys Mol Biol. 2004 May;85(1):1—32.
