Stem cell (satellite cells) aging in muscle tissue, influence of stem cell niches on this process, possibility of adult stem cell rejuvenation by changes in their microenvironment through transmembrane receptor protein Notch

Place of work — (Department
of Neurology and
Neurological Sciences
Stanford University
School of Medicine, USA
Contacts — Department of Neurology Room A-343, Stanford University Medical Center Stanford, CA 94305–5235 USA 650-493-5000, ext. 63731, 63730, or 62073 rando@stanford.edu
Publications — Rejuvenation of aged progenitor cells by exposure to a young systemic environment. Conboy IM, Conboy MJ, Wagers AJ, Girma ER, Weissman IL, Rando TA. Nature. 2005 Feb 17;433(7027):760–4.
Turning back time: reversing tissue pathology to enhance stem cell engraftment. Rando TA. Cell Stem Cell. 2008 Sep 11;3(3):232–4.
Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis. Brack AS, Conboy MJ, Roy S, Lee M, Kuo CJ, Keller C, Rando TA. Science. 2007 Aug 10;317(5839):807–10. PMID: 17690295