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Implication of transforming growth factor-beta in osteoporosis development

Place of work — Department
of Biochemistry and
Molecular Biology, Mayo
Clinic, USA
Contacts — Mayo Clinic Cancer Center, 200 First Street SW, Rochester, MN 55905, USA (507) 285–0712 oursler.merryjo@mayo.edu http://mayoresearch.mayo.edu/mayo/research/staff/oursler_mj.cfm
Publications — TGF-beta coordinately activates TAK1/MEK/AKT/NFkB and SMAD pathways to promote osteoclast survival. Gingery A., Bradley E.W., Pederson L., Ruan Mю, Horwood N.J., Oursler M. J. Exp. Cell Res. 2008 Sep 10;314(15):2725–38.
Regulation of bone formation by osteoclasts involves Wnt/BMP signaling and the chemokine sphingosine-1-phosphate. Pederson L., Ruan M., Westendorf J.J., Khosla S., Oursler M. J. Proc. Natl. Acad. Sci. USA. 2008 Dec 30;105(52):20764–9.
Pathway crosstalk between Ras/Raf and PI3K in promotion of M-CSF-induced MEK/ERK- mediated osteoclast survival. Bradley E.W., Ruan M.M., Vrable A., Oursler M.J. J Cell Bio- chem. 2008 Jul 1;104(4):1439–51.