Directed homologous recombination, reparation of double strand breaks, sickle-cell disease, devising of gene therapy methods

Place of work — Children’s — Hematology-
Oncology Simmons
Comprehensive Cancer
Center, Dallas, USA
Contacts — 5323 Harry Hines Blvd, Dallas, TX 75390–9063, USA (214) 648–3896 matthew.porteus@ utsouthwestern.edu
Publications — Mammalian Gene Targeting with Designed Zinc Finger Nucleases. Porteus MH. Mol Ther. 2006 Feb;13(2):438–46
Chimeric nucleases stimulate gene targeting in human cells. Porteus MH, Baltimore D. Science. 2003 May 2;300(5620):763
Efficient gene targeting mediated by adeno-associated virus and DNA double-strand breaks. Porteus MH, Cathomen T, Weitzman MD, Baltimore D. Mol Cell Biol. 2003 May;23(10):3558–65.