Assessment of cytoprotective action of pharmacological drugs, vitamin B complex and biologically active substances in conditions of carbonil and oxidative stress

Place of work — Department
of Pharmaceutical
Sciences, Faculty of
Pharmacy, University of
Toronto, Canada
Contacts — Leslie Dan Faculty of Pharmacy University of Toronto 144 College Street Toronto, Ontario M5S 3M2. (416) 978–2716 peter.obrien@utoronto.ca http://www.pharmacy.utoronto.ca/graduate/faculty/obrien.jsp
Publications — Cytoprotective mechanisms of carbonyl scavenging drugs in isolated rat hepatocytes. Mehta R., Wong L., O’Brien P. J. Chemю Biolю Interact. 2009 Mar 16;178(1–3):317–23.
Hepatocyte cytotoxicity induced by hydroperoxide (oxidative stress model) or glyoxal (carbonylation model): prevention by bioactive nut extracts or catechins. Banach M.S., Dong Q., O’Brien P. J. Chem. Biol. Interact. 2009 Mar 16;178(1–3):324–31.
Preventing cell death induced by carbonyl stress, oxidative stress or mitochondrial toxins with vitamin B anti-AGE agents. Mehta R., Shangari N., O’Brien P. J. Mol. Nutr. Food Res. 2008 Mar;52(3):379–85.