Systematic study of cryoprotectors, search, prediction and development of new cryoprotective compounds

The area of A. Kompaniets’s scientific interest is the investigation of homological series of chemical compounds — polyols, amides and their derivatives, products of the directed synthesis; the ascertainment the type of a relation between cryoprotective activity, cytotoxicity, compound toxicity, structure and physicochemical properties. She realizes in her work one of the ways of creation and obtaining of new cryoprotectors — chemical modification of the known compounds. Research areas linked to phase transition and development of methods allowing to direct it, so that it is possible to optimize the technology of low-temperature conservation of different cell suspensions and tissues, are also an important part of A. Kompaniets’s investigations. In A. Kompaniets’s laboratory, data allowing to handle recrystallization processes, such as «crystal-crystal», «vitrification-devitrification», in the media with various cryoprotectors (such additives as carbohydrates, proteins, surfactants etc.) were obtained. At present, solutions containing cryoprotectors and bioactive substances, which will allow to freeze bodies of warm-blooded animals to ultralow temperatures, are tested in the department led by A. Kompaniets.

Place of employment — Institute for Problems of Cryobiology and Cryomedicine NAS, Ukraine.

Contacts — Ukraine, 61015, Kharkov, Pereyaslavskaya str., 23 +38 (057) 373-4143cryo@online.kharkov.ua .

Publications — Platelet transfusions in systemic blood diseases. Agranenko VA, Kompaniets AM, Kaveshnikova BF. Gematol Transfuziol. 1994 Mar-Apr;39(2):32–7.Physical states of aqueous solutions of oxyethylated glycerol with polymerization degree of n=30 at temperatures lower than 283 K. Zhivotova EN, Zinchenko AV, Kuleshova LG, Chekanova VV, Kompaniets AM. Cryo Letters. 2007 Jul-Aug;28(4):261–70.