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SUBSTITUTED BICYCLIC AZA-HETEROCYCLES AND ANALOGUES AS SIRTUIN MODULATORS

Link
https://patentscope.wipo.int/search/en/detail.jsf?docId=US124053947&recNum=187&office=&queryString=FP%3A%28%28FP%3Aaging+AND+IC%3AA+%29%29&prevFilter=&sortOption=Pub+Date+Desc&maxRec=14953
Название компании
SUBSTITUTED BICYCLIC AZA-HETEROCYCLES AND ANALOGUES AS SIRTUIN MODULATORS
Country
USA
Applicant
GlaxoSmithKline, LLC
Patent num
20140349993
(International) Application No
14353096 and PCT/US12/61015
patent date
19.10.2012
Description

Provided herein are novel substituted bicyclic aza-heterocycle sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.