In Dr. M. Lokhandwala’s laboratory, the role of oxidative stress in cardiovascular diseases is investigated. The scientists have studied how physical activity (running on the special race track) affects markers of oxidative stress in old rats. The researchers have shown that physical activity increases the level of transcription factors which induce expression of proteins protecting from active forms of oxygen. Thus, the scientists concluded that physical activity reduces consequences of oxidative stress during aging.
Place of employment — University of Houston, USA.
Contacts — 4800 Calhoun Road, Houston, Texas 77004 (713) 743–2255 mlokandwala@uh.edu
Publications — Exercise Stimulates Transcription Factors (Nrf2 & NFkB), Increases Antioxidant Defenses, Decreases Oxidative Stress, and Restores Renal Dopamine D1 Receptor Function in Aging. George L, Mohammad A., Lokhandwala M. The FASEB Journal. 2008;22:1159.6Exercise decreases oxidative stress and inflammation and restores renal dophamine D1 receptor function in old rats. Mohammad A., George L., Lokhandwala M. Am J Physiol Renal Physiol. 2007; 293:
